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Chinese Journal of Joint Surgery(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (02): 200-206. doi: 10.3877/ cma.j.issn.1674-134X.2025.02.010

• REVIEWS • Previous Articles    

Recent advances in immune and inflammatory mechanisms of gout

Qi Yan1, Zhijun Zhao2, Binbin Zhang1, Shuqing Wei1, Bin Dou1, Kewen Li3,()   

  1. 1. Clinical Medical College of Qinghai University, Xining 810000,China
    2. Qinghai Provincial Institute for Endemic Disease Prevention and Control, Xining 810000, China
    3. Affiliated Hospital of Qinghai University, Xining 810000,China
  • Received:2024-11-15 Online:2025-04-01 Published:2025-06-17
  • Contact: Kewen Li

Abstract:

Gout is an autoinflammatory disease characterized by acute or chronic inflammation and osteoarticular damage due to precipitation of monosodium urate crystals. Recent studies have shown that a variety of immune cells such as macrophages and T lymphocytes play a key role in the occurrence,development and reversal of gout in the pathogenesis of gout, and some inflammatory cytokines, such as those in the interleukin-1 family, have been shown to play anti-inflammatory or proinflammatory roles in gouty inflammation, but the specific mechanism is unknown. This article aimed to start from the role of immune cells and inflammatory factors in the occurrence and development of gout, and provide new ideas for further elucidating the pathogenesis of gout.

Key words: Gout, Leukocytes, Interleukins, Inflammasomes, Uric acid

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